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Target
GTPase KRas
Ligand
BDBM50648627
Substrate
n/a
Meas. Tech.
ChEMBL_2486813
IC50
0.689000±n/a nM
Citation
 Kargbo, RB Innovative Therapeutic Approaches Targeting K-Ras: Analysis of Macrocyclic Compounds, Peptidomimetics, and Pyridopyrimidine Inhibitors. ACS Med Chem Lett 15:1196-1198[PubMed] 
Target
Name:
GTPase KRas
Synonyms:
GTPase KRas, N-terminally processed | K-Ras 2 | Ki-Ras | c-K-ras | c-Ki-ras | RASK_HUMAN | KRAS | KRAS2 | RASK2
Type:
PROTEIN
Mol. Mass.:
21656.10
Organism:
Human
Description:
ChEMBL_1476955
Residue:
189
Sequence:
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM
  
Inhibitor
Name:
BDBM50648627
Synonyms:
CHEMBL5612057
Type:
Small organic molecule
Emp. Form.:
C31H27F4N5O2
Mol. Mass.:
585.63
SMILES:
[2H]C([2H])([2H])N(c1nc(OC([2H])([2H])C23CCC([2H])([2H])N2C[C@@]([2H])(F)C3)nc2c(F)c(-c3cc(O)cc4ccc(F)c(C#C)c34)ncc12)[C@H]1C[C@@H]1F
Structure:
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