Reaction Details Report a problem with these data
Target
Pachytene checkpoint protein 2 homolog
Ligand
BDBM50649211
Substrate
n/a
Meas. Tech.
ChEMBL_2488939
Kd
2.7±n/a nM
Citation
 Li, X; Zhang, H; Dong, S; Gao, X; Sun, H; Zhou, Z; Hu, K; Guo, S; Zhang, Q; Guo, Z; Jacob Bunu, S; Zhu, J; Li, B; Zhang, Y; Shen, J; Akber Aisa, H; Xu, Z; Cai, H; Shi, J; Zhu, W Design, synthesis, and biological evaluation of novel 1-amido-2-one-4-thio-deoxypyranose as potential antitumor agents for multiple myeloma. Bioorg Med Chem 111:0[PubMed] 
Target
Name:
Pachytene checkpoint protein 2 homolog
Synonyms:
16E1-BP | HPV16 E1 protein-binding protein | Human papillomavirus type 16 E1 protein-binding protein | Pachytene checkpoint protein 2 homolog | PCH2 | Thyroid hormone receptor interactor 13 | Thyroid receptor-interacting protein 13 | TR-interacting protein 13 | TRIP-13 | TRIP13
Type:
PROTEIN
Mol. Mass.:
48546.70
Organism:
Homo sapiens
Description:
ChEMBL_121296
Residue:
432
Sequence:
MDEAVGDLKQALPCVAESPTVHVEVHQRGSSTAKKEDINLSVRKLLNRHNIVFGDYTWTEFDEPFLTRNVQSVSIIDTELKVKDSQPIDLSACTVALHIFQLNEDGPSSENLEEETENIIAANHWVLPAAEFHGLWDSLVYDVEVKSHLLDYVMTTLLFSDKNVNSNLITWNRVVLLHGPPGTGKTSLCKALAQKLTIRLSSRYRYGQLIEINSHSLFSKWFSESGKLVTKMFQKIQDLIDDKDALVFVLIDEVESLTAARNACRAGTEPSDAIRVVNAVLTQIDQIKRHSNVVILTTSNITEKIDVAFVDRADIKQYIGPPSAAAIFKIYLSCLEELMKCQIIYPRQQLLTLRELEMIGFIENNVSKLSLLLNDISRKSEGLSGRVLRKLPFLAHALYVQAPTVTIEGFLQALSLAVDKQFEERKKLAAYI
  
Inhibitor
Name:
BDBM50649211
Synonyms:
CHEMBL5618290
Type:
Small organic molecule
Emp. Form.:
C23H23NO8S
Mol. Mass.:
473.50
SMILES:
COc1ccc(SC2CC(=O)[C@H](NC(=O)c3ccc4c(c3)OCO4)O[C@@H]2COC(C)=O)cc1
Structure:
Search PDB for entries with ligand similarity: