Reaction Details Report a problem with these data
Target
Stimulator of interferon genes protein
Ligand
BDBM50605474
Substrate
n/a
Meas. Tech.
ChEMBL_2489398
IC50
76±n/a nM
Citation
 Hu, B; Cui, Y; Lee, JJ; Ma, JX; Duerfeldt, AS Design and Assessment of First-Generation Heterobifunctional PPARĪ±/STING Modulators. ACS Med Chem Lett 15:1279-1286[PubMed] 
Target
Name:
Stimulator of interferon genes protein
Synonyms:
Mediator of IRF3 activation | Transmembrane protein 173 | Endoplasmic reticulum interferon stimulator | Synonyms=ERIS | hSTING | hMITA | STING_HUMAN | STING1 | ERIS | MITA | STING | TMEM173
Type:
Protein
Mol. Mass.:
42215.19
Organism:
Human
Description:
Q86WV6
Residue:
379
Sequence:
MPHSSLHPSIPCPRGHGAQKAALVLLSACLVTLWGLGEPPEHTLRYLVLHLASLQLGLLLNGVCSLAEELRHIHSRYRGSYWRTVRACLGCPLRRGALLLLSIYFYYSLPNAVGPPFTWMLALLGLSQALNILLGLKGLAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS
  
Inhibitor
Name:
BDBM50605474
Synonyms:
CHEMBL5189857
Type:
Small organic molecule
Emp. Form.:
C25H19FN2O4S
Mol. Mass.:
462.50
SMILES:
Oc1ccc(NC(=O)c2ccc(cc2)-c2ccccc2)cc1NS(=O)(=O)c1ccc(F)cc1
Structure:
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