Reaction Details Report a problem with these data
Target
Stimulator of interferon genes protein
Ligand
BDBM50649406
Substrate
n/a
Meas. Tech.
ChEMBL_2489398
IC50
8100±n/a nM
Citation
 Hu, B; Cui, Y; Lee, JJ; Ma, JX; Duerfeldt, AS Design and Assessment of First-Generation Heterobifunctional PPARĪ±/STING Modulators. ACS Med Chem Lett 15:1279-1286[PubMed] 
Target
Name:
Stimulator of interferon genes protein
Synonyms:
Mediator of IRF3 activation | Transmembrane protein 173 | Endoplasmic reticulum interferon stimulator | Synonyms=ERIS | hSTING | hMITA | STING_HUMAN | STING1 | ERIS | MITA | STING | TMEM173
Type:
Protein
Mol. Mass.:
42215.19
Organism:
Human
Description:
Q86WV6
Residue:
379
Sequence:
MPHSSLHPSIPCPRGHGAQKAALVLLSACLVTLWGLGEPPEHTLRYLVLHLASLQLGLLLNGVCSLAEELRHIHSRYRGSYWRTVRACLGCPLRRGALLLLSIYFYYSLPNAVGPPFTWMLALLGLSQALNILLGLKGLAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS
  
Inhibitor
Name:
BDBM50649406
Synonyms:
CHEMBL5619812
Type:
Small organic molecule
Emp. Form.:
C20H16FNO3
Mol. Mass.:
337.35
SMILES:
O=C(O)c1cc(NCc2ccc(-c3ccc(F)cc3)cc2)ccc1O
Structure:
Search PDB for entries with ligand similarity: