Reaction Details Report a problem with these data
Target
cGMP-dependent protein kinase 1
Ligand
BDBM101618
Substrate
n/a
Meas. Tech.
ChEMBL_2543589
Ki
15±n/a nM
Citation
 Murray, BW; Guo, C; Piraino, J; Westwick, JK; Zhang, C; Lamerdin, J; Dagostino, E; Knighton, D; Loi, CM; Zager, M; Kraynov, E; Popoff, I; Christensen, JG; Martinez, R; Kephart, SE; Marakovits, J; Karlicek, S; Bergqvist, S; Smeal, T Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth. Proc Natl Acad Sci U S A 107:9446-51[PubMed] 
Target
Name:
cGMP-dependent protein kinase 1
Synonyms:
GMP-dependent protein kinase I | cGMP-dependent protein kinase 1 | Protein Kinase G | cGMP-dependent protein kinase 1 beta | cGMP-dependent protein kinase | KGP1_HUMAN | PRKG1 | PRKG1B | PRKGR1A | PRKGR1B
Type:
Protein
Mol. Mass.:
76358.04
Organism:
Human
Description:
Q13976
Residue:
671
Sequence:
MSELEEDFAKILMLKEERIKELEKRLSEKEEEIQELKRKLHKCQSVLPVPSTHIGPRTTRAQGISAEPQTYRSFHDLRQAFRKFTKSERSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVNVTREDSPSEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVTCLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAEAAFFANLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNDEPPPDDNSGWDIDF
  
Inhibitor
Name:
BDBM101618
Synonyms:
US8530652, 114
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
Cc1nc2ccsc2c(n1)Nc3c4c([nH]n3)C(N(C4)C(=O)N[C@H](CN(C)C)c5ccccc5)(C)C
Structure:
Search PDB for entries with ligand similarity: