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Target
Muscarinic acetylcholine receptor M2
Ligand
BDBM50259847
Substrate
n/a
Meas. Tech.
ChEMBL_525848 (CHEMBL972958)
IC50
>5517±n/a nM
Citation
 Ikeda, Y; Nonaka, H; Furumai, T; Igarashi, Y Cremastrine, a pyrrolizidine alkaloid from Cremastra appendiculata. J Nat Prod 68:572-3 (2005) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M2
Synonyms:
Cholinergic, muscarinic M2 | RecName: Full=Muscarinic acetylcholine receptor M2 | ACM2_HUMAN | CHRM2 | Muscarinic acetylcholine receptor M2 and M5 | Muscarinic acetylcholine receptor M2 and M4
Type:
GPCR
Mol. Mass.:
51730.61
Organism:
Human
Description:
P08172
Residue:
466
Sequence:
MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
  
Inhibitor
Name:
BDBM50259847
Synonyms:
cremastrine | CHEMBL480464
Type:
Small organic molecule
Emp. Form.:
C14 H25 N O3
Mol. Mass.:
255.3532
SMILES:
CC[C@@H](C)[C@@H](O)C(=O)OC[C@H]1CCN2CCC[C@@H]12 |r|
Structure:
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