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Target
Muscarinic acetylcholine receptor M4
Ligand
BDBM50259847
Substrate
n/a
Meas. Tech.
ChEMBL_525850 (CHEMBL972960)
IC50
498±n/a nM
Citation
 Ikeda, Y; Nonaka, H; Furumai, T; Igarashi, Y Cremastrine, a pyrrolizidine alkaloid from Cremastra appendiculata. J Nat Prod 68:572-3 (2005) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M4
Synonyms:
Cholinergic, muscarinic M4 | Muscarinic acetylcholine receptor | ACM4_HUMAN | CHRM4 | Muscarinic acetylcholine receptor M2 and M4
Type:
Enzyme Catalytic Domain
Mol. Mass.:
53079.31
Organism:
Human
Description:
Cholinergic, muscarinic M4 CHRM4 HUMAN M3::P08173
Residue:
479
Sequence:
MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
  
Inhibitor
Name:
BDBM50259847
Synonyms:
cremastrine | CHEMBL480464
Type:
Small organic molecule
Emp. Form.:
C14 H25 N O3
Mol. Mass.:
255.3532
SMILES:
CC[C@@H](C)[C@@H](O)C(=O)OC[C@H]1CCN2CCC[C@@H]12 |r|
Structure:
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