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Target
Sodium-dependent serotonin transporter
Ligand
BDBM30130
Substrate
n/a
Meas. Tech.
ChEMBL_487423 (CHEMBL1020017)
IC50
9.4±n/a nM
Citation
 Mahaney, PE; Gavrin, LK; Trybulski, EJ; Stack, GP; Vu, TA; Cohn, ST; Ye, F; Belardi, JK; Santilli, AA; Sabatucci, JP; Leiter, J; Johnston, GH; Bray, JA; Burroughs, KD; Cosmi, SA; Leventhal, L; Koury, EJ; Zhang, Y; Mugford, CA; Ho, DM; Rosenzweig-Lipson, SJ; Platt, B; Smith, VA; Deecher, DC Structure-activity relationships of the cycloalkanol ethylamine scaffold: discovery of selective norepinephrine reuptake inhibitors. J Med Chem 51:4038-49 (2008) [PubMed]  Article 
Target
Name:
Sodium-dependent serotonin transporter
Synonyms:
5-HT Transporter | 5HT transporter | 5HTT | Serotonin Transporter (SERT) | Serotonin transporter (5HTT) | Serotonin transporter protein (SERT) | Sodium-dependent serotonin transporter (SERT) | Solute carrier family 6 member 4 | SC6A4_HUMAN | SLC6A4 | HTT | SERT
Type:
Multi-pass membrane protein
Mol. Mass.:
70322.51
Organism:
Human
Description:
P31645
Residue:
630
Sequence:
METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTRHSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIITPGTFKERIIKSITPETPTEIPCGDIRLNAV
  
Inhibitor
Name:
BDBM30130
Synonyms:
Prozac | cid_62857 | Fluoxetin | CHEMBL41 | CHEMBL1201082 | Fluoxetine | US9120771, Fluoxetine
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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