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Target
Purine nucleoside phosphorylase
Ligand
BDBM50252865
Substrate
n/a
Meas. Tech.
ChEMBL_534715 (CHEMBL982804)
Ki
3.60±n/a nM
Citation
 Mason, JM; Murkin, AS; Li, L; Schramm, VL; Gainsford, GJ; Skelton, BW A beta-fluoroamine inhibitor of purine nucleoside phosphorylase. J Med Chem 51:5880-4 (2008) [PubMed]  Article 
Target
Name:
Purine nucleoside phosphorylase
Synonyms:
Purine Nucleoside Phosphorylase (PNP) | pfPNP
Type:
Enzyme
Mol. Mass.:
26857.85
Organism:
Plasmodium falciparum
Description:
n/a
Residue:
245
Sequence:
MDNLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYA
  
Inhibitor
Name:
BDBM50252865
Synonyms:
(+/-)-cis-1-((9-Deazahypoxanthin-9-yl)methyl)-4-fluoro-4-hydroxymethylpyrrolidin-3-ol | (3S,4S)-1-((9-Deazahypoxanthin-9-yl)methyl)-4-fluoro-4-hydroxymethyl pyrrolidin-3-ol | CHEMBL498940 | Immucillins, 1
Type:
Small organic molecule
Emp. Form.:
C12H15FN4O3
Mol. Mass.:
282.2709
SMILES:
OC[C@@]1(F)CN(Cc2c[nH]c3c2nc[nH]c3=O)C[C@@H]1O |r|
Structure:
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