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Target
Protein-tyrosine kinase 2-beta
Ligand
BDBM50246060
Substrate
n/a
Meas. Tech.
ChEMBL_558212 (CHEMBL962346)
IC50
31±n/a nM
Citation
 Walker, DP; Bi, FC; Kalgutkar, AS; Bauman, JN; Zhao, SX; Soglia, JR; Aspnes, GE; Kung, DW; Klug-McLeod, J; Zawistoski, MP; McGlynn, MA; Oliver, R; Dunn, M; Li, JC; Richter, DT; Cooper, BA; Kath, JC; Hulford, CA; Autry, CL; Luzzio, MJ; Ung, EJ; Roberts, WG; Bonnette, PC; Buckbinder, L; Mistry, A; Griffor, MC; Han, S; Guzman-Perez, A Trifluoromethylpyrimidine-based inhibitors of proline-rich tyrosine kinase 2 (PYK2): structure-activity relationships and strategies for the elimination of reactive metabolite formation. Bioorg Med Chem Lett 18:6071-7 (2008) [PubMed]  Article 
Target
Name:
Protein-tyrosine kinase 2-beta
Synonyms:
Protein tyrosine kinase 2 beta | PTK2B protein tyrosine kinase 2 beta | PTK2B protein tyrosine kinase 2 beta (PTK2B) | FAK2_HUMAN | PTK2B | FAK2 | PYK2 | RAFTK
Type:
Protein
Mol. Mass.:
115868.80
Organism:
Human
Description:
Q14289
Residue:
1009
Sequence:
MSGVSEPLSRVKLGTLRRPEGPAEPMVVVPVDVEKEDVRILKVCFYSNSFNPGKNFKLVKCTVQTEIREIITSILLSGRIGPNIRLAECYGLRLKHMKSDEIHWLHPQMTVGEVQDKYECLHVEAEWRYDLQIRYLPEDFMESLKEDRTTLLYFYQQLRNDYMQRYASKVSEGMALQLGCLELRRFFKDMPHNALDKKSNFELLEKEVGLDLFFPKQMQENLKPKQFRKMIQQTFQQYASLREEECVMKFFNTLAGFANIDQETYRCELIQGWNITVDLVIGPKGIRQLTSQDAKPTCLAEFKQIRSIRCLPLEEGQAVLQLGIEGAPQALSIKTSSLAEAENMADLIDGYCRLQGEHQGSLIIHPRKDGEKRNSLPQIPMLNLEARRSHLSESCSIESDIYAEIPDETLRRPGGPQYGIAREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHIVKLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESINFRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYDPSDRPRFTELVCSLSDVYQMEKDIAMEQERNARYRTPKILEPTAFQEPPPKPSRPKYRPPPQTNLLAPKLQFQVPEGLCASSPTLTSPMEYPSPVNSLHTPPLHRHNVFKRHSMREEDFIQPSSREEAQQLWEAEKVKMRQILDKQQKQMVEDYQWLRQEEKSLDPMVYMNDKSPLTPEKEVGYLEFTGPPQKPPRLGAQSIQPTANLDRTDDLVYLNVMELVRAVLELKNELCQLPPEGYVVVVKNVGLTLRKLIGSVDDLLPSLPSSSRTEIEGTQKLLNKDLAELINKMRLAQQNAVTSLSEECKRQMLTASHTLAVDAKNLLDAVDQAKVLANLAHPPAE
  
Inhibitor
Name:
BDBM50246060
Synonyms:
CHEMBL472212 | N-methyl-N-(2-((2-(2-oxoindolin-5-ylamino)-5-(trifluoromethyl)pyrimidin-4-ylamino)methyl)phenyl)methanesulfonamide | N-methyl-N-{2-[({2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl}amino)methyl]phenyl}methanesulfonamide | CHEMBL541649 | PF-431396 | D3RKN_6
Type:
Small organic molecule
Emp. Form.:
C22H21F3N6O3S
Mol. Mass.:
506.13
SMILES:
CN(c1ccccc1CNc2c(cnc(n2)Nc3ccc4c(c3)CC(=O)N4)C(F)(F)F)S(=O)(=O)C
Structure:
Search PDB for entries with ligand similarity: