Reaction Details Report a problem with these data
Target
Histone deacetylase 1
Ligand
BDBM50275363
Substrate
n/a
Meas. Tech.
ChEMBL_493106 (CHEMBL940369)
IC50
7±n/a nM
Citation
 Methot, JL; Hamblett, CL; Mampreian, DM; Jung, J; Harsch, A; Szewczak, AA; Dahlberg, WK; Middleton, RE; Hughes, B; Fleming, JC; Wang, H; Kral, AM; Ozerova, N; Cruz, JC; Haines, B; Chenard, M; Kenific, CM; Secrist, JP; Miller, TA SAR profiles of spirocyclic nicotinamide derived selective HDAC1/HDAC2 inhibitors (SHI-1:2). Bioorg Med Chem Lett 18:6104-9 (2008) [PubMed]  Article 
Target
Name:
Histone deacetylase 1
Synonyms:
HD1 | Histone deacetylase 1 (HDAC1) | Human HDAC1 | HDAC1_HUMAN | HDAC1 | RPD3L1 | Cereblon/Histone deacetylase 1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Human
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM50275363
Synonyms:
N-(2-amino-5-(thiophen-2-yl)phenyl)-6-(2-oxo-1,3,8-triazaspiro[4.5]decan-8-yl)nicotinamide | CHEMBL486152
Type:
Small organic molecule
Emp. Form.:
C23 H24 N6 O2 S
Mol. Mass.:
448.54066
SMILES:
Nc1ccc(cc1NC(=O)c1ccc(nc1)N1CCC2(CNC(=O)N2)CC1)-c1cccs1
Structure:
Search PDB for entries with ligand similarity: