Reaction Details Report a problem with these data
Target
Amine oxidase [flavin-containing] B
Ligand
BDBM50265993
Substrate
n/a
Meas. Tech.
ChEMBL_540261 (CHEMBL1033163)
Ki
1380±n/a nM
Citation
 Sant' Anna, Gda S; Machado, P; Sauzem, PD; Rosa, FA; Rubin, MA; Ferreira, J; Bonacorso, HG; Zanatta, N; Martins, MA Ultrasound promoted synthesis of 2-imidazolines in water: a greener approach toward monoamine oxidase inhibitors. Bioorg Med Chem Lett 19:546-9 (2008) [PubMed]  Article 
Target
Name:
Amine oxidase [flavin-containing] B
Synonyms:
Monoamine oxidase B (rMAO-B) | Monoamine oxidase | Monoamine oxidase B (MAO-B) | Monoamine oxidase-B (MAO-B) | Amine oxidase [flavin-containing] B | Amine oxidase (flavin-containing) B | Monoamine oxidase type B (MAOB) | AOFB_RAT | Maob | Monoamine Oxidase Type B (MAO-B)
Type:
Enzyme
Mol. Mass.:
58469.65
Organism:
Rat
Description:
P19643
Residue:
520
Sequence:
MSNKCDVIVVGGGISGMAAAKLLHDCGLSVVVLEARDRVGGRTYTIRNKNVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHFVKGKSYAFRGPFPPVWNPITYLDYNNLWRTMDEMGQEIPSDAPWKAPLAEEWDYMTMKELLDKICWTNSTKQIATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFIGGSGQVSERIKDILGDRVKLERPVIHIDQTGENVVVKTLNHEIYEAKYVISAIPPVLGMKIHHSPPLPILRNQLITRVPLGSVIKCMVYYKEPFWRKKDFCGTMVIEGEEAPIAYTLDDTKPDGSCAAIMGFILAHKARKLVRLTKEERLRKLCELYAKVLNSQEALQPVHYEEKNWCEEQYSGGCYTAYFPPGILTQYGRVLRQPVGKIFFAGTETASHWSGYMEGAVEAGERAAREILHAIGKIPEDEIWQPEPESVDVPARPITNTFLERHLPSVPGLLKLLGLTTILSATALGFLAHKKGLFVRF
  
Inhibitor
Name:
BDBM50265993
Synonyms:
phenyl 4-(4,5-dihydro-1H-imidazol-2-yl)benzoate | CHEMBL451230
Type:
Small organic molecule
Emp. Form.:
C16 H14 N2 O2
Mol. Mass.:
266.29456
SMILES:
O=C(Oc1ccccc1)c1ccc(cc1)C1=NCCN1 |t:17|
Structure:
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