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Target
3-oxoacyl-[acyl-carrier-protein] synthase 3
Ligand
BDBM50276688
Substrate
n/a
Meas. Tech.
ChEMBL_541154 (CHEMBL1030715)
Kd
141000±n/a nM
Citation
 Lee, JY; Jeong, KW; Lee, JU; Kang, DI; Kim, Y Novel E. coli beta-ketoacyl-acyl carrier protein synthase III inhibitors as targeted antibiotics. Bioorg Med Chem 17:1506-13 (2009) [PubMed]  Article 
Target
Name:
3-oxoacyl-[acyl-carrier-protein] synthase 3
Synonyms:
3-oxoacyl-[acyl-carrier-protein] synthase | 3-oxoacyl-[acyl-carrier-protein] synthase III | 3-oxoacyl-[acyl-carrier-protein] synthase 3 | Beta-ketoacyl-ACP synthase III (FabH)
Type:
Enzyme
Mol. Mass.:
33506.68
Organism:
Escherichia coli
Description:
C3TDZ2
Residue:
317
Sequence:
MYTKIIGTGSYLPEQVRTNADLEKMVDTSDEWIVTRTGIRERHIAAPNETVSTMGFEAATRAIEMAGIEKDQIGLIVVATTSATHAFPSAACQIQSMLGIKGCPAFDVAAACAGFTYALSVADQYVKSGAVKYALVVGSDVLARTCDPTDRGTIIIFGDGAGAAVLAASEEPGIISTHLHADGSYGELLTLPNADRVNPENSIHLTMAGNEVFKVAVTELAHIVDETLAANNLDRSQLDWLVPHQANLRIISATAKKLGMSMDNVVVTLDRHGNTSAASVPCALDEAVRDGRIKPGQLVLLEAFGGGFTWGSALVRF
  
Inhibitor
Name:
BDBM50276688
Synonyms:
3-(1-methyl-4-(phenylamino)-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino)propan-1-ol | CHEMBL513094
Type:
Small organic molecule
Emp. Form.:
C15 H18 N6 O
Mol. Mass.:
298.34302
SMILES:
Cn1ncc2c(Nc3ccccc3)nc(NCCCO)nc12
Structure:
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