Reaction Details Report a problem with these data
Target
Retinoic acid receptor beta
Ligand
BDBM50290182
Substrate
n/a
Meas. Tech.
ChEMBL_195811 (CHEMBL807722)
Kd
>1000±n/a nM
Citation
 Beard, RL; Teng, M; Colon, DF; Duong, TT; Thacher, SM; Arefieg, T; Chandraratna, RA Synthesis and biological activity of 1,2,3,4-tetrahydroquinoline and 3,4-(1H)-dihydroquinolin-2-one analogs of retinoic acid Bioorg Med Chem Lett 7:2373-2378 (1997)    Article 
Target
Name:
Retinoic acid receptor beta
Synonyms:
RAR-beta | RAR-epsilon | HBV-activated protein | Nuclear receptor subfamily 1 group B member 2 | Retinoic acid receptor beta | RARB_HUMAN | RARB | HAP | NR1B2 | Retinoic acid receptor RXR-alpha/Retinoic acid receptor beta | Retinoid receptor
Type:
PROTEIN
Mol. Mass.:
50498.70
Organism:
Human
Description:
ChEMBL_1458015
Residue:
455
Sequence:
MTTSGHACPVPAVNGHMTHYPATPYPLLFPPVIGGLSLPPLHGLHGHPPPSGCSTPSPATIETQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKETSKQECTESYEMTAELDDLTEKIRKAHQETFPSLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGHEPLTPSSSGNTAEHSPSISPSSVENSGVSQSPLVQ
  
Inhibitor
Name:
BDBM50290182
Synonyms:
4-(4,4-Dimethyl-2-oxo-1,2,3,4-tetrahydro-quinolin-7-ylethynyl)-benzoic acid | CHEMBL306999
Type:
Small organic molecule
Emp. Form.:
C20 H17 N O3
Mol. Mass.:
319.35388
SMILES:
CC1(C)CC(=O)Nc2cc(ccc12)C#Cc1ccc(cc1)C(O)=O
Structure:
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