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Target
Stearoyl-CoA desaturase
Ligand
BDBM50298907
Substrate
n/a
Meas. Tech.
ChEMBL_588106 (CHEMBL1044832)
IC50
0.5±n/a nM
Citation
 Koltun, DO; Zilbershtein, TM; Migulin, VA; Vasilevich, NI; Parkhill, EQ; Glushkov, AI; McGregor, MJ; Brunn, SA; Chu, N; Hao, J; Mollova, N; Leung, K; Chisholm, JW; Zablocki, J Potent, orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors. Bioorg Med Chem Lett 19:4070-4 (2009) [PubMed]  Article 
Target
Name:
Stearoyl-CoA desaturase
Synonyms:
Acyl-CoA desaturase | Stearoyl-CoA (SCD1) | SCD_HUMAN | SCD | FADS5 | SCD1 | SCDOS | Stearoyl-CoA desaturase 1
Type:
Enzyme
Mol. Mass.:
41537.27
Organism:
Human
Description:
O00767
Residue:
359
Sequence:
MPAHLLQDDISSSYTTTTTITAPPSRVLQNGGDKLETMPLYLEDDIRPDIKDDIYDPTYKDKEGPSPKVEYVWRNIILMSLLHLGALYGITLIPTCKFYTWLWGVFYYFVSALGITAGAHRLWSHRSYKARLPLRLFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEKGSTLDLSDLEAEKLVMFQRRYYKPGLLMMCFILPTLVPWYFWGETFQNSVFVATFLRYAVVLNATWLVNSAAHLFGYRPYDKNISPRENILVSLGAVGEGFHNYHHSFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAILARIKRTGDGNYKSG
  
Inhibitor
Name:
BDBM50298907
Synonyms:
N-(2-(6-(3,4-dichlorobenzylamino)-3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl)ethyl)-2-hydroxyacetamide | CHEMBL572876
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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