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Target
Tissue alpha-L-fucosidase
Ligand
BDBM50065258
Substrate
n/a
Meas. Tech.
ChEMBL_604167 (CHEMBL1039761)
Ki
3±n/a nM
Citation
 Pearson, MS; Floquet, N; Bello, C; Vogel, P; Plantier-Royon, R; Szymoniak, J; Bertus, P; Behr, JB The spirocyclopropyl moiety as a methyl surrogate in the structure of l-fucosidase and l-rhamnosidase inhibitors. Bioorg Med Chem 17:8020-6 (2009) [PubMed]  Article 
Target
Name:
Tissue alpha-L-fucosidase
Synonyms:
Alpha-L-fucosidase 1 | FUCA1 | FUCO_BOVIN
Type:
PROTEIN
Mol. Mass.:
54093.12
Organism:
Bos taurus
Description:
ChEMBL_335897
Residue:
468
Sequence:
MRSWVVGARLLLLLQLVLVLGAVRLPPCTDPRHCTDPPRYTPDWPSLDSRPLPAWFDEAKFGVFVHWGVFSVPAWGSEWFWWHWQGEKLPQYESFMKENYPPDFSYADFGPRFTARFFNPDSWADLFKAAGAKYVVLTTKHHEGYTNWPSPVSWNWNSKDVGPHRDLVGELGTAIRKRNIRYGLYHSLLEWFHPLYLRDKKNGFKTQYFVNAKTMPELYDLVNRYKPDLIWSDGEWECPDTYWNSTDFLAWLYNDSPVKDEVVVNDRWGQNCSCHHGGYYNCKDKFQPETLPDHKWEMCTSIDQRSWGYRRDMEMADITNESTIISELVQTVSLGGNYLLNVGPTKDGLIVPIFQERLLAVGKWLSINGEAIYASKPWRVQSEKNSVWYTSKGLAVYAILLHWPEYGILSLISPIATSTTKVTMLGIQKDLKWSLNPSGKGLLVFLPQLPPAALPTEFAWTIKLTGVK
  
Inhibitor
Name:
BDBM50065258
Synonyms:
(2S,3R,4S,5R)-2-Methyl-piperidine-3,4,5-triol | (2S,3R,4S,5R)-2-methylpiperidine-3,4,5-triol | CHEMBL314772 | Fucosidase Inhibitor, 3
Type:
Small organic molecule
Emp. Form.:
C6H13NO3
Mol. Mass.:
147.1723
SMILES:
C[C@@H]1NC[C@@H](O)[C@H](O)[C@@H]1O
Structure:
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