Reaction Details Report a problem with these data
Target
U4/U6 small nuclear ribonucleoprotein Prp4
Ligand
BDBM16673
Substrate
n/a
Meas. Tech.
ChEMBL_655903 (CHEMBL1244947)
Kd
>10000±n/a nM
Citation
 Zarrinkar, PP; Gunawardane, RN; Cramer, MD; Gardner, MF; Brigham, D; Belli, B; Karaman, MW; Pratz, KW; Pallares, G; Chao, Q; Sprankle, KG; Patel, HK; Levis, M; Armstrong, RC; James, J; Bhagwat, SS AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML). Blood 114:2984-92 (2009) [PubMed]  Article 
Target
Name:
U4/U6 small nuclear ribonucleoprotein Prp4
Synonyms:
PRP4 homolog | U4/U6 snRNP 60 kDa protein | WD splicing factor Prp4 | hPrp4 | PRP4_HUMAN | PRPF4 | PRP4
Type:
PROTEIN
Mol. Mass.:
58457.58
Organism:
Human
Description:
ChEMBL_655903
Residue:
522
Sequence:
MASSRASSTQATKTKAPDDLVAPVVKKPHIYYGSLEEKERERLAKGESGILGKDGLKAGIEAGNINITSGEVFEIEEHISERQAEVLAEFERRKRARQINVSTDDSEVKACLRALGEPITLFGEGPAERRERLRNILSVVGTDALKKTKKDDEKSKKSKEEYQQTWYHEGPNSLKVARLWIANYSLPRAMKRLEEARLHKEIPETTRTSQMQELHKSLRSLNNFCSQIGDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWMAE
  
Inhibitor
Name:
BDBM16673
Synonyms:
Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide | 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-picolinamide;tosylic acid | Sorafenib, 4 | Hit compound, 8 | Sorafenib | Nexavar | cid_216239 | BAY 439006 | US9029401, Sorafenib | US9469639, Sorafenib | US10183928, Sorafenib | US10202365, Compound Sorafenib | US10227329, Compound Sorafenib | US9902709, Comparative example 1 | US10584114, Compound Sorafenib | US10774070, Compound Sorafenib | US10980809, Example Sorafenib | US11505527, Compound Sorafenib | US11279688, Compound Sorafenib | US11912663, Compound Sorafenib
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: