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Target
RAC-gamma serine/threonine-protein kinase
Ligand
BDBM15131
Substrate
n/a
Meas. Tech.
ChEMBL_662184 (CHEMBL1252175)
IC50
51±n/a nM
Citation
 Okuzumi, T; Fiedler, D; Zhang, C; Gray, DC; Aizenstein, B; Hoffman, R; Shokat, KM Inhibitor hijacking of Akt activation. Nat Chem Biol 5:484-93 (2009) [PubMed]  Article 
Target
Name:
RAC-gamma serine/threonine-protein kinase
Synonyms:
Protein kinase B (Akt 3) | PKB gamma | Serine/threonine-protein kinase AKT3 | Protein kinase B, gamma | Protein kinase Akt-3 | RAC-PK-gamma | RAC-gamma serine/threonine-protein kinase | STK-2 | AKT3_HUMAN | AKT3 | PKBG | Serine/threonine-protein kinase AKT
Type:
Enzyme
Mol. Mass.:
55769.36
Organism:
Human
Description:
n/a
Residue:
479
Sequence:
MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQLMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCSPTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTITITPPEKYDEDGMDCMDNERRPHFPQFSYSASGRE
  
Inhibitor
Name:
BDBM15131
Synonyms:
5-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridin-3-yl}-3-methyl-1H-indazole | 5-indazolyl pyridine 3 | indazole-pyridine, 4 | A-443654
Type:
Small organic molecule
Emp. Form.:
C24H23N5O
Mol. Mass.:
397.19
SMILES:
Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2c[nH]c3ccccc23)c1 |r|
Structure:
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