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Target
Lactoylglutathione lyase
Ligand
BDBM54705
Substrate
n/a
Meas. Tech.
ChEMBL_716549 (CHEMBL1670273)
Ki
400000±n/a nM
Citation
 Yuan, M; Luo, M; Song, Y; Xu, Q; Wang, X; Cao, Y; Bu, X; Ren, Y; Hu, X Identification of curcumin derivatives as human glyoxalase I inhibitors: A combination of biological evaluation, molecular docking, 3D-QSAR and molecular dynamics simulation studies. Bioorg Med Chem 19:1189-96 (2011) [PubMed]  Article 
Target
Name:
Lactoylglutathione lyase
Synonyms:
Glyoxalase I | Methylglyoxalase | S-D-lactoylglutathione methylglyoxal lyase | Ketone-aldehyde mutase | Glx I | Aldoketomutase | LGUL_HUMAN | GLO1 | Glyoxalase 1 (GLO1)
Type:
Enzyme
Mol. Mass.:
20772.95
Organism:
Human
Description:
Q04760
Residue:
184
Sequence:
MAEPQPPSGGLTDEAALSCCSDADPSTKDFLLQQTMLRVKDPKKSLDFYTRVLGMTLIQKCDFPIMKFSLYFLAYEDKNDIPKEKDEKIAWALSRKATLELTHNWGTEDDETQSYHNGNSDPRGFGHIGIAVPDVYSACKRFEELGVKFVKKPDDGKMKGLAFIQDPDGYWIEILNPNKMATLM
  
Inhibitor
Name:
BDBM54705
Synonyms:
calcium;2-(3-phenoxyphenyl)propanoic acid;hydrate | cid_16219353 | CHEMBL1297 | UNM-0000306101 | Fenoprofen | calcium;2-(3-phenoxyphenyl)propionic acid;hydrate
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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