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Target
Sodium- and chloride-dependent GABA transporter 2
Ligand
BDBM84684
Substrate
n/a
Meas. Tech.
ChEMBL_745625 (CHEMBL1775995)
IC50
223872±n/a nM
Citation
 Hack, S; Wörlein, B; Höfner, G; Pabel, J; Wanner, KT Development of imidazole alkanoic acids as mGAT3 selective GABA uptake inhibitors. Eur J Med Chem 46:1483-98 (2011) [PubMed]  Article 
Target
Name:
Sodium- and chloride-dependent GABA transporter 2
Synonyms:
GABA transporter 3 | S6A13_MOUSE | Slc6a13 | Gabt2 | Gabt3 | Gat-3 | Gat2 | Gat3 | GABA transporter
Type:
PROTEIN
Mol. Mass.:
68283.40
Organism:
Mouse
Description:
ChEMBL_1460089
Residue:
602
Sequence:
MENRASGTTSNGETKPVCPAMEKVEEDGTLEREHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLIFLFTCGIPVFFLETALGQYTNQGGITAWRRICPIFEGIGYASQMIVSLLNVYYIVVLAWALFYLFSSFTTDLPWGSCSHEWNTENCVEFQKANDSMNVTSENATSPVIEFWERRVLKLSDGIQHLGSLRWELVLCLLLAWIICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVTLPGAAQGIQFYLYPNITRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCILNSSTSFMAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPRVFRKKNRREVLILIVSVISFFIGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGAGRFYDNIEDMIGYKPWPLIKYCWLFFTPAVCLATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLALSSMICIPAWSIYKLRTLKGPLRERLRQLVCPAEDLPQKNQPEPTAPATPMTSLLRLTELESNC
  
Inhibitor
Name:
BDBM84684
Synonyms:
CHEMBL543494 | 1-Subsituted 1H-imidazole, 21
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: