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Target
Fructose-1,6-bisphosphatase 1
Ligand
BDBM50305589
Substrate
n/a
Meas. Tech.
ChEMBL_748172 (CHEMBL1781851)
IC50
330±n/a nM
Citation
 Hebeisen, P; Haap, W; Kuhn, B; Mohr, P; Wessel, HP; Zutter, U; Kirchner, S; Ruf, A; Benz, J; Joseph, C; Alvarez-Sánchez, R; Gubler, M; Schott, B; Benardeau, A; Tozzo, E; Kitas, E Orally active aminopyridines as inhibitors of tetrameric fructose-1,6-bisphosphatase. Bioorg Med Chem Lett 21:3237-42 (2011) [PubMed]  Article 
Target
Name:
Fructose-1,6-bisphosphatase 1
Synonyms:
Fructose-1,6-bisphosphatase 1 | D-fructose-1,6-bisphosphate 1-phosphohydrolase 1 | FBPase 1 | Fructose-1,6-bisphosphatase | F16P1_HUMAN | FBP1 | FBP | Fructose-1,6-bisphosphatase 1 (FBPase)
Type:
Protein
Mol. Mass.:
36843.58
Organism:
Human
Description:
Liver FBPase (P09467)
Residue:
338
Sequence:
MADQAPFDTDVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGKEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHSAQ
  
Inhibitor
Name:
BDBM50305589
Synonyms:
N-(5-bromothiazol-2-ylcarbamoyl)-3-chlorobenzenesulfonamide | CHEMBL595149
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: