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Target
Casein kinase I isoform alpha
Ligand
BDBM50326053
Substrate
n/a
Meas. Tech.
ChEMBL_774326 (CHEMBL1908543)
Kd
>10000±n/a nM
Citation
 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol 29:1046-51 (2011) [PubMed]  Article 
Target
Name:
Casein kinase I isoform alpha
Synonyms:
Casein Kinase I | Casein kinase 1 alpha (CK1 alpha) | CK1 | CKI-alpha | KC1A_HUMAN | CSNK1A1 | Casein kinase I isoform alpha/delta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
38936.59
Organism:
Human
Description:
P48729
Residue:
337
Sequence:
MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQAASSSGQGQQAQTPTGKQTDKTKSNMKGF
  
Inhibitor
Name:
BDBM50326053
Synonyms:
PKC-412 | CHEMBL608533 | US20240132489, Compound Staurosporine
Type:
Small organic molecule
Emp. Form.:
C35H30N4O4
Mol. Mass.:
n/a
SMILES:
C[C@@]12[C@@H]([C@@H](C[C@@H](O1)n3c4ccccc4c5c3c6n2c7ccccc7c6c8c5C(=O)NC8)N(C)C(=O)c9ccccc9)OC
Structure:
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