Reaction Details Report a problem with these data
Target
Casein kinase I isoform alpha
Ligand
BDBM50026612
Substrate
n/a
Meas. Tech.
ChEMBL_774326 (CHEMBL1908543)
Kd
>10000±n/a nM
Citation
 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol 29:1046-51 (2011) [PubMed]  Article 
Target
Name:
Casein kinase I isoform alpha
Synonyms:
Casein Kinase I | Casein kinase 1 alpha (CK1 alpha) | CK1 | CKI-alpha | KC1A_HUMAN | CSNK1A1 | Casein kinase I isoform alpha/delta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
38936.59
Organism:
Human
Description:
P48729
Residue:
337
Sequence:
MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQAASSSGQGQQAQTPTGKQTDKTKSNMKGF
  
Inhibitor
Name:
BDBM50026612
Synonyms:
BIBF-1120 | Nintedanib | Vargatef | US10981896, Compound Nintedanib | US11208381, Nintedanib | US11046672, Nintedanib
Type:
Small organic molecule
Emp. Form.:
C31H33N5O4
Mol. Mass.:
539.25
SMILES:
CN1CCN(CC1)CC(=O)N(C)c2ccc(cc2)N/C(=C\3/c4ccc(cc4NC3=O)C(=O)OC)/c5ccccc5
Structure:
Search PDB for entries with ligand similarity: