Reaction Details Report a problem with these data
Target
Casein kinase I isoform alpha
Ligand
BDBM5446
Substrate
n/a
Meas. Tech.
ChEMBL_774326 (CHEMBL1908543)
Kd
>10000±n/a nM
Citation
 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol 29:1046-51 (2011) [PubMed]  Article 
Target
Name:
Casein kinase I isoform alpha
Synonyms:
Casein Kinase I | Casein kinase 1 alpha (CK1 alpha) | CK1 | CKI-alpha | KC1A_HUMAN | CSNK1A1 | Casein kinase I isoform alpha/delta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
38936.59
Organism:
Human
Description:
P48729
Residue:
337
Sequence:
MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQAASSSGQGQQAQTPTGKQTDKTKSNMKGF
  
Inhibitor
Name:
BDBM5446
Synonyms:
Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine | CHEMBL553 | ERLOTINIB HYDROCHLORIDE | cid_176870 | Erotinib | N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine Monohydrochloride | Tarceva | US9409845, Table 1, Compound 22: erlotinib | US10189853, erlotinib | US9730934, Erlotinib | US10507209, Compound Erlotinib | US11524945, Compound Erlotinib | WO2022090481, Example erlotinib
Type:
Small organic molecule
Emp. Form.:
C22H23N3O4
Mol. Mass.:
393.17
SMILES:
COCCOc1cc2c(cc1OCCOC)ncnc2Nc3cccc(c3)C#C
Structure:
Search PDB for entries with ligand similarity: