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Target
Bone morphogenetic protein receptor type-1A
Ligand
BDBM16673
Substrate
n/a
Meas. Tech.
ChEMBL_774425 (CHEMBL1908642)
Kd
>10000±n/a nM
Citation
 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol 29:1046-51 (2011) [PubMed]  Article 
Target
Name:
Bone morphogenetic protein receptor type-1A
Synonyms:
BMR1A_HUMAN | BMPR1A | ACVRLK3 | ALK3 | Activin receptor-like kinase 3 (ALK-3)
Type:
Enzyme
Mol. Mass.:
60204.46
Organism:
Human
Description:
P36894
Residue:
532
Sequence:
MPQLYIYIRLLGAYLFIISRVQGQNLDSMLHGTGMKSDSDQKKSENGVTLAPEDTLPFLKCYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQCKDSPKAQLRRTIECCRTNLCNQYLQPTLPPVVIGPFFDGSIRWLVLLISMAVCIIAMIIFSSCFCYKHYCKSISSRRRYNRDLEQDEAFIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQMVRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQGKPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPEVLDESLNKNHFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYEDMREVVCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTLAKMVESQDVKI
  
Inhibitor
Name:
BDBM16673
Synonyms:
Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide | 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-picolinamide;tosylic acid | Sorafenib, 4 | Hit compound, 8 | Sorafenib | Nexavar | cid_216239 | BAY 439006 | US9029401, Sorafenib | US9469639, Sorafenib | US10183928, Sorafenib | US10202365, Compound Sorafenib | US10227329, Compound Sorafenib | US9902709, Comparative example 1 | US10584114, Compound Sorafenib | US10774070, Compound Sorafenib | US10980809, Example Sorafenib | US11505527, Compound Sorafenib | US11279688, Compound Sorafenib | US11912663, Compound Sorafenib | US20250129067, Compound Sorafenib
Type:
Small organic molecule
Emp. Form.:
C21H16ClF3N4O3
Mol. Mass.:
464.09
SMILES:
CNC(=O)c1cc(ccn1)Oc2ccc(cc2)NC(=O)Nc3ccc(c(c3)C(F)(F)F)Cl
Structure:
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