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Target
Muscarinic acetylcholine receptor M2
Ligand
BDBM50355610
Substrate
n/a
Meas. Tech.
ChEMBL_776522 (CHEMBL1913619)
Ki
0.48±n/a nM
Citation
 Glossop, PA; Watson, CA; Price, DA; Bunnage, ME; Middleton, DS; Wood, A; James, K; Roberts, D; Strang, RS; Yeadon, M; Perros-Huguet, C; Clarke, NP; Trevethick, MA; Machin, I; Stuart, EF; Evans, SM; Harrison, AC; Fairman, DA; Agoram, B; Burrows, JL; Feeder, N; Fulton, CK; Dillon, BR; Entwistle, DA; Spence, FJ Inhalation by design: novel tertiary amine muscarinic M3 receptor antagonists with slow off-rate binding kinetics for inhaled once-daily treatment of chronic obstructive pulmonary disease. J Med Chem 54:6888-904 (2011) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M2
Synonyms:
Cholinergic, muscarinic M2 | RecName: Full=Muscarinic acetylcholine receptor M2 | ACM2_HUMAN | CHRM2 | Muscarinic acetylcholine receptor M2 and M5 | Muscarinic acetylcholine receptor M2 and M4
Type:
GPCR
Mol. Mass.:
51730.61
Organism:
Human
Description:
P08172
Residue:
466
Sequence:
MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
  
Inhibitor
Name:
BDBM50355610
Synonyms:
CHEMBL1237108
Type:
Small organic molecule
Emp. Form.:
C20H30BrNO3
Mol. Mass.:
n/a
SMILES:
CC(C)[N+]1([C@H]2CC[C@@H]1CC(C2)OC(=O)[C@@H](CO)c3ccccc3)C
Structure:
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