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Target
Tyrosine-protein kinase Blk
Ligand
BDBM50357333
Substrate
n/a
Meas. Tech.
ChEMBL_787370 (CHEMBL1919249)
IC50
16±n/a nM
Citation
 Kim, KH; Maderna, A; Schnute, ME; Hegen, M; Mohan, S; Miyashiro, J; Lin, L; Li, E; Keegan, S; Lussier, J; Wrocklage, C; Nickerson-Nutter, CL; Wittwer, AJ; Soutter, H; Caspers, N; Han, S; Kurumbail, R; Dunussi-Joannopoulos, K; Douhan, J; Wissner, A Imidazo[1,5-a]quinoxalines as irreversible BTK inhibitors for the treatment of rheumatoid arthritis. Bioorg Med Chem Lett 21:6258-63 (2011) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase Blk
Synonyms:
B lymphoid tyrosine kinase | Tyrosine-protein kinase BLK (BLK) | p55-Blk | BLK_HUMAN | BLK | SRC
Type:
Protein
Mol. Mass.:
57711.88
Organism:
Human
Description:
P51451
Residue:
505
Sequence:
MGLVSSKKPDKEKPIKEKDKGQWSPLKVSAQDKDAPPLPPLVVFNHLTPPPPDEHLDEDKHFVVALYDYTAMNDRDLQMLKGEKLQVLKGTGDWWLARSLVTGREGYVPSNFVARVESLEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGELIKHYKIRCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQNPWAQDEWEIPRQSLRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLYAVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRDLRAANILVSEALCCKIADFGLARIIDSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEERPTFEFLQSVLEDFYTATERQYELQP
  
Inhibitor
Name:
BDBM50357333
Synonyms:
CHEMBL1916891
Type:
Small organic molecule
Emp. Form.:
C24H25FN6O
Mol. Mass.:
n/a
SMILES:
CN(C)C\C=C\C(=O)N(C)c1cc2c(cc1F)nc(Nc1ccccc1C)c1cncn21
Structure:
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