Reaction Details Report a problem with these data
Target
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
Ligand
BDBM50357881
Substrate
n/a
Meas. Tech.
ChEMBL_787634 (CHEMBL1918087)
Kd
250±n/a nM
Citation
 Anraku, K; Inoue, T; Sugimoto, K; Kudo, K; Okamoto, Y; Morii, T; Mori, Y; Otsuka, M Design and synthesis of biotinylated inositol 1,3,4,5-tetrakisphosphate targeting Grp1 pleckstrin homology domain. Bioorg Med Chem 19:6833-41 (2011) [PubMed]  Article 
Target
Name:
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
Synonyms:
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-1 | PLC-III | PLC-delta-1 | Phosphoinositide phospholipase C | PLCD1_HUMAN | PLCD1 | Phospholipase C-delta-1
Type:
PROTEIN
Mol. Mass.:
85666.51
Organism:
Human
Description:
ChEMBL_787634
Residue:
756
Sequence:
MDSGRDFLTLHGLQDDEDLQALLKGSQLLKVKSSSWRRERFYKLQEDCKTIWQESRKVMRTPESQLFSIEDIQEVRMGHRTEGLEKFARDVPEDRCFSIVFKDQRNTLDLIAPSPADAQHWVLGLHKIIHHSGSMDQRQKLQHWIHSCLRKADKNKDNKMSFKELQNFLKELNIQVDDSYARKIFRECDHSQTDSLEDEEIEAFYKMLTQRVEIDRTFAEAAGSGETLSVDQLVTFLQHQQREEAAGPALALSLIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQDMGQPLSHYLVSSSHNTYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKILFCDVLRAIRDYAFKASPYPVILSLENHCTLEQQRVMARHLHAILGPMLLNRPLDGVTNSLPSPEQLKGKILLKGKKLGGLLPPGGEGGPEATVVSDEDEAAEMEDEAVRSRVQHKPKEDKLRLAQELSDMVIYCKSVHFGGFSSPGTPGQAFYEMASFSENRALRLLQESGNGFVRHNVGHLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYQGRFQDNGACGYVLKPAFLRDPNGTFNPRALAQGPWWARKRLNIRVISGQQLPKVNKNKNSIVDPKVTVEIHGVSRDVASRQTAVITNNGFNPWWDTEFAFEVVVPDLALIRFLVEDYDASSKNDFIGQSTIPLNSLKQGYRHVHLMSKNGDQHPSATLFVKISLQD
  
Inhibitor
Name:
BDBM50357881
Synonyms:
CHEMBL1916340
Type:
Small organic molecule
Emp. Form.:
C22H43N3O20P4S
Mol. Mass.:
825.11
SMILES:
O[C@H]1[C@@H](OP(O)(=O)OCCCCCCNC(=O)CCCC[C@@H]2SC[C@@H]3NC(=O)N[C@H]23)[C@H](O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H]1OP(O)(O)=O |r|
Structure:
Search PDB for entries with ligand similarity: