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Target
Broad substrate specificity ATP-binding cassette transporter ABCG2
Ligand
BDBM29134
Substrate
n/a
Meas. Tech.
ChEMBL_795925 (CHEMBL1936798)
IC50
6070±n/a nM
Citation
 Juvale, K; Pape, VF; Wiese, M Investigation of chalcones and benzochalcones as inhibitors of breast cancer resistance protein. Bioorg Med Chem 20:346-55 (2011) [PubMed]  Article 
Target
Name:
Broad substrate specificity ATP-binding cassette transporter ABCG2
Synonyms:
CDw338 | Urate exporter | ATP-binding cassette, sub-family G, member 2 | ATP-binding cassette sub-family G member 2 | Placenta-specific ATP-binding cassette transporter | Breast cancer resistance protein | Mitoxantrone resistance-associated protein | ATP-binding cassette transporter (ABCG2) | ATP-Binding Cassette Transporter ABCG2 | ABCG2_HUMAN | ABCG2 | ABCP | BCRP | BCRP1 | MXR
Type:
Multi-pass membrane protein; monomer or homodimer; disulfide-linked
Mol. Mass.:
72329.48
Organism:
Human
Description:
Q9UNQ0
Residue:
655
Sequence:
MSSSNVEVFIPVSQGNTNGFPATASNDLKAFTEGAVLSFHNICYRVKLKSGFLPCRKPVEKEILSNINGIMKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPANFKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADFFLDIINGDSTAVALNREEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKETKAELHQLSGGEKKKKITVFKEISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVIGAIYFGLKNDSTGIQNRAGVLFFLTTNQCFSSVSAVELFVVEKKLFIHEYISGYYRVSSYFLGKLLSDLLPMRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIAAGQSVVSVATLLMTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGFTALQHNEFLGQNFCPGLNATGNNPCNYATCTGEEYLVKQGIDLSPWGLWKNHVALACMIVIFLTIAYLKLLFLKKYS
  
Inhibitor
Name:
BDBM29134
Synonyms:
substituted chalcone, 5m
Type:
Small organic molecule
Emp. Form.:
C15H11ClO3
Mol. Mass.:
274.04
SMILES:
Oc1ccc(C(=O)\C=C\c2ccc(Cl)cc2)c(O)c1
Structure:
Search PDB for entries with ligand similarity: