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Target
Misshapen-like kinase 1
Ligand
BDBM50361467
Substrate
n/a
Meas. Tech.
ChEMBL_797145 (CHEMBL1942372)
IC50
6±n/a nM
Citation
 Millan, DS; Bunnage, ME; Burrows, JL; Butcher, KJ; Dodd, PG; Evans, TJ; Fairman, DA; Hughes, SJ; Kilty, IC; Lemaitre, A; Lewthwaite, RA; Mahnke, A; Mathias, JP; Philip, J; Smith, RT; Stefaniak, MH; Yeadon, M; Phillips, C Design and synthesis of inhaled p38 inhibitors for the treatment of chronic obstructive pulmonary disease. J Med Chem 54:7797-814 (2011) [PubMed]  Article 
Target
Name:
Misshapen-like kinase 1
Synonyms:
Misshapen/NIK-related kinase | Mitogen-activated protein kinase kinase kinase kinase 6 | MEK kinase kinase 6 | GCK family kinase MiNK | MEKKK 6 | MAPK/ERK kinase kinase kinase 6 | MINK1_HUMAN | MINK1 | B55 | MAP4K6 | MINK | YSK2 | ZC3 | Voltage-gated potassium channel subunit Kv7.1/Misshapen-like kinase 1 | Misshapen-like kinase 1 (MINK)
Type:
PROTEIN
Mol. Mass.:
149838.92
Organism:
Human
Description:
ChEMBL_793919
Residue:
1332
Sequence:
MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPGPPAQPPGPPNASSNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPVLSPGNKAKPDDHRSRPGRPADFVLLKERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEGSRDTPGGRSDGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEERNLLHADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDSIPITALVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW
  
Inhibitor
Name:
BDBM50361467
Synonyms:
CHEMBL1938400
Type:
Small organic molecule
Emp. Form.:
C35H34ClN7O3S2
Mol. Mass.:
n/a
SMILES:
CC(C)(C)c1cc(NC(=O)NCc2ccccc2Sc2ccc3nnc(-c4ccccc4SCCO)n3c2)n(n1)-c1ccc(O)c(Cl)c1
Structure:
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