Reaction Details
Report a problem with these data
Report a problem with these dataTarget
Matrix metalloproteinase-15
Ligand
BDBM50365344
Substrate
n/a
Meas. Tech.
ChEMBL_806648 (CHEMBL1960131)
Ki
>10000±n/a nM
Citation
Brown, MF; Reilly, U; Abramite, JA; Arcari, JT; Oliver, R; Barham, RA; Che, Y; Chen, JM; Collantes, EM; Chung, SW; Desbonnet, C; Doty, J; Doroski, M; Engtrakul, JJ; Harris, TM; Huband, M; Knafels, JD; Leach, KL; Liu, S; Marfat, A; Marra, A; McElroy, E; Melnick, M; Menard, CA; Montgomery, JI; Mullins, L; Noe, MC; O'Donnell, J; Penzien, J; Plummer, MS; Price, LM; Shanmugasundaram, V; Thoma, C; Uccello, DP; Warmus, JS; Wishka, DG Potent inhibitors of LpxC for the treatment of Gram-negative infections. J Med Chem 55:914-23 (2012) [PubMed] Article More Info.:
Target
Name:
Matrix metalloproteinase-15
Synonyms:
MMP-15 | MMP15 | MMP15_HUMAN | MT-MMP 2 | MT2-MMP | MT2MMP | MTMMP2 | Matrix metalloproteinase 15 | Matrix metalloproteinase-15 | Membrane-type matrix metalloproteinase 2 | Membrane-type-2 matrix metalloproteinase | SMCP-2
Type:
PROTEIN
Mol. Mass.:
75814.08
Organism:
Homo sapiens (Human)
Description:
ChEMBL_106793
Residue:
669
Sequence:
MGSDPSAPGRPGWTGSLLGDREEAARPRLLPLLLVLLGCLGLGVAAEDAEVHAENWLRLYGYLPQPSRHMSTMRSAQILASALAEMQRFYGIPVTGVLDEETKEWMKRPRCGVPDQFGVRVKANLRRRRKRYALTGRKWNNHHLTFSIQNYTEKLGWYHSMEAVRRAFRVWEQATPLVFQEVPYEDIRLRRQKEADIMVLFASGFHGDSSPFDGTGGFLAHAYFPGPGLGGDTHFDADEPWTFSSTDLHGNNLFLVAVHELGHALGLEHSSNPNAIMAPFYQWKDVDNFKLPEDDLRGIQQLYGTPDGQPQPTQPLPTVTPRRPGRPDHRPPRPPQPPPPGGKPERPPKPGPPVQPRATERPDQYGPNICDGDFDTVAMLRGEMFVFKGRWFWRVRHNRVLDNYPMPIGHFWRGLPGDISAAYERQDGRFVFFKGDRYWLFREANLEPGYPQPLTSYGLGIPYDRIDTAIWWEPTGHTFFFQEDRYWRFNEETQRGDPGYPKPISVWQGIPASPKGAFLSNDAAYTYFYKGTKYWKFDNERLRMEPGYPKSILRDFMGCQEHVEPGPRWPDVARPPFNPHGGAEPGADSAEGDVGDGDGDFGAGVNKDGGSRVVVQMEEVARTVNVVMVLVPLLLLLCVLGLTYALVQMQRKGAPRVLLYCKRSLQEWV
Inhibitor
Name:
BDBM50365344
Synonyms:
CHEMBL1956115
Type:
Small organic molecule
Emp. Form.:
C18H21NO4S
Mol. Mass.:
347.429
SMILES:
C[C@@](CCc1ccc(cc1)-c1ccccc1)(C(=O)NO)S(C)(=O)=O |r|
Structure:
