Reaction Details Report a problem with these data
Target
Tissue alpha-L-fucosidase
Ligand
BDBM50104390
Substrate
n/a
Meas. Tech.
ChEMBL_33942 (CHEMBL649568)
Ki
210±n/a nM
Citation
Robina, I; Moreno-Vargas, AJ; Fernández-Bolaños, JG; Fuentes, J; Demange, R; Vogel, P New leads for selective inhibitors of alpha-L-fucosidases. Synthesis and glycosidase inhibitory activities of [(2R,3S,4R)-3,4-dihydroxypyrrolidin-2-yl]furan derivatives. Bioorg Med Chem Lett 11:2555-9 (2001) [PubMed] Article
More Info.:
Target
Name:
Tissue alpha-L-fucosidase
Synonyms:
Alpha-L-fucosidase I | Alpha-L-fucoside fucohydrolase | FUCA1 | FUCO_HUMAN | Tissue alpha-L-fucosidase
Type:
PROTEIN
Mol. Mass.:
53690.69
Organism:
Homo sapiens (Human)
Description:
ChEMBL_34088
Residue:
466
Sequence:
MRAPGMRSRPAGPALLLLLLFLGAAESVRRAQPPRRYTPDWPSLDSRPLPAWFDEAKFGVFIHWGVFSVPAWGSEWFWWHWQGEGRPQYQRFMRDNYPPGFSYADFGPQFTARFFHPEEWADLFQAAGAKYVVLTTKHHEGFTNWPSPVSWNWNSKDVGPHRDLVGELGTALRKRNIRYGLYHSLLEWFHPLYLLDKKNGFKTQHFVSAKTMPELYDLVNSYKPDLIWSDGEWECPDTYWNSTNFLSWLYNDSPVKDEVVVNDRWGQNCSCHHGGYYNCEDKFKPQSLPDHKWEMCTSIDKFSWGYRRDMALSDVTEESEIISELVQTVSLGGNYLLNIGPTKDGLIVPIFQERLLAVGKWLSINGEAIYASKPWRVQWEKNTTSVWYTSKGSAVYAIFLHWPENGVLNLESPITTSTTKITMLGIQGDLKWSTDPDKGLFISLPQLPPSAVPAEFAWTIKLTGVK
Inhibitor
Name:
BDBM50104390
Synonyms:
(R)-2-((R)-2-Allyloxy-4,5-dihydroxy-6-hydroxymethyl-tetrahydro-pyran-3-yloxy)-6-methyl-tetrahydro-thiopyran-3,4,5-triol | CHEMBL85817
Type:
Small organic molecule
Emp. Form.:
C15H26O9S
Mol. Mass.:
382.427
SMILES:
CC1SC(O[C@H]2C(OCC=C)OC(CO)C(O)C2O)C(O)[C@H](O)C1O