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Target
Sodium-dependent dopamine transporter
Ligand
BDBM50021952
Substrate
n/a
Meas. Tech.
ChEBML_193333
Ki
7.2±n/a nM
Citation
 Maryanoff, BE; McComsey, DF; Gardocki, JF; Shank, RP; Costanzo, MJ; Nortey, SO; Schneider, CR; Setler, PE Pyrroloisoquinoline antidepressants. 2. In-depth exploration of structure-activity relationships. J Med Chem 30:1433-54 (1987) [PubMed]  Article 
Target
Name:
Sodium-dependent dopamine transporter
Synonyms:
DA transporter | Sodium-dependent dopamine transporter (DAT) | SC6A3_RAT | Slc6a3 | Monoamine transporters; Norepininephrine & dopamine | Sodium-dependent dopamine transporter
Type:
Multi-pass membrane protein
Mol. Mass.:
68749.45
Organism:
Rat
Description:
P23977
Residue:
619
Sequence:
MSKSKCSVGPMSSVVAPAKESNAVGPREVELILVKEQNGVQLTNSTLINPPQTPVEAQERETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFFSSFTMDLPWIHCNNTWNSPNCSDAHASNSSDGLGLNDTFGTTPAAEYFERGVLHLHQSRGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAMDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSFSSGFVVFSFLGYMAQKHNVPIRDVATDGPGLIFIIYPEAIATLPLSSAWAAVFFLMLLTLGIDSAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIVTFRPPHYGAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPGSFREKLAYAITPEKDHQLVDRGEVRQFTLRHWLLL
  
Inhibitor
Name:
BDBM50021952
Synonyms:
CHEMBL35337 | 7-Benzyl-1-ethyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid | Amfonelic acid
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
CCn1cc(C(O)=O)c(=O)c2ccc(Cc3ccccc3)nc12
Structure:
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