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Target
Substance-P receptor
Ligand
BDBM50016451
Substrate
n/a
Meas. Tech.
ChEBML_198108
Ki
>10000±n/a nM
Citation
 Jacobson, KA; Lipkowski, AW; Moody, TW; Padgett, W; Pijl, E; Kirk, KL; Daly, JW Binary drugs: conjugates of purines and a peptide that bind to both adenosine and substance P receptors. J Med Chem 30:1529-32 (1987) [PubMed]  Article 
Target
Name:
Substance-P receptor
Synonyms:
SPR | Substance-P receptor | NK-1R | Tachykinin receptor 1 | NK-1 receptor | Neurokinin NK1 | NK1 Receptor | NK1R_RAT | Tacr1 | Tac1r | Neurokinin 1 receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46371.54
Organism:
Rat
Description:
Competition binding assays were carried out using membrane preparations from transfected CHO cells that constitutively expressed the rat NK1 receptor.
Residue:
407
Sequence:
MDNVLPMDSDLFPNISTNTSESNQFVQPTWQIVLWAAAYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNRTYEKAYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHVFFLLPYINPDLYLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQSSVYKVSRLETTISTVVGAHEEEPEEGPKATPSSLDLTSNGSSRSNSKTMTESSSFYSNMLA
  
Inhibitor
Name:
BDBM50016451
Synonyms:
CHEMBL37306 | N-[2-(2-Amino-acetylamino)-ethyl]-2-[4-(2,6-dioxo-1,3-dipropyl-2,3,4,5,6,7-hexahydro-1H-purin-8-yl)-phenoxy]-acetamide
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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