Reaction Details Report a problem with these data
Target
Dihydrofolate reductase
Ligand
BDBM50367343
Substrate
n/a
Meas. Tech.
ChEMBL_54398 (CHEMBL667355)
pH
7.0000±n/a
Kd
810±n/a nM
Comments
extracted
Citation
 Taira, K; Benkovic, SJ Evaluation of the importance of hydrophobic interactions in drug binding to dihydrofolate reductase. J Med Chem 31:129-37 (1988) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
dfrA17 | Dihydrofolate reductase (F31V)
Type:
n/a
Mol. Mass.:
17532.46
Organism:
Escherichia coli
Description:
n/a
Residue:
157
Sequence:
MKISLISAVSESGVIGSGPDIPWSVKGEQLLFKALTYNQWLLVGRKTFDSMGVLPNRKYAVVSKNGISSSNENVLVFPSIENALKELSKVTDHVYVSGGGQIYNSLIEKADIIHLSTVHVEVEGDIKFPIMPENFNLVFEQFFMSNINYTYQIWKKG
  
Inhibitor
Name:
BDBM50367343
Synonyms:
Folacin | FOLIC ACID | (2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid | Folvite | Vitamin B9 | Vitamin M
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: