Reaction Details Report a problem with these data
Target
Dihydrofolate reductase
Ligand
BDBM18044
Substrate
n/a
Meas. Tech.
ChEMBL_54409 (CHEMBL667167)
pH
7.0000±n/a
Temperature
298.1500±n/a K
Kd
6600±n/a nM
Citation
 Taira, K; Benkovic, SJ Evaluation of the importance of hydrophobic interactions in drug binding to dihydrofolate reductase. J Med Chem 31:129-37 (1988) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
dfrA17 | Dihydrofolate reductase (F31V)
Type:
n/a
Mol. Mass.:
17532.46
Organism:
Escherichia coli
Description:
n/a
Residue:
157
Sequence:
MKISLISAVSESGVIGSGPDIPWSVKGEQLLFKALTYNQWLLVGRKTFDSMGVLPNRKYAVVSKNGISSSNENVLVFPSIENALKELSKVTDHVYVSGGGQIYNSLIEKADIIHLSTVHVEVEGDIKFPIMPENFNLVFEQFFMSNINYTYQIWKKG
  
Inhibitor
Name:
BDBM18044
Synonyms:
(S)-2-{4-[(2-Amino-4-hydroxy-7,8-dihydro-pteridin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid | (2S)-2-[(4-{[(2-amino-4-oxo-1,4,7,8-tetrahydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioic acid | dihydrofolic acid
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: