Reaction Details Report a problem with these data
Target
Aldo-keto reductase family 1 member B1 [K65Q]
Ligand
BDBM50022424
Substrate
n/a
Meas. Tech.
ChEBML_31633
IC50
100±n/a nM
Citation
 Sarges, R; Schnur, RC; Belletire, JL; Peterson, MJ Spiro hydantoin aldose reductase inhibitors. J Med Chem 31:230-43 (1988) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1 [K65Q]
Synonyms:
ALDR_BOVIN | AKR1B1 | Aldose reductase
Type:
Protein
Mol. Mass.:
35916.27
Organism:
Bovine
Description:
P16116[K65Q]
Residue:
315
Sequence:
AHNIVLYTGAKMPILGLGTWKSPPGKVTEAVKVAIDLGYRHIDCAHVYQNENEVGLALQAKLQEQVVKREDLFIVSKLWCTYHDKDLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKDFFPLDEDGNVIPSEKDFVDTWTAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKPAVNQIECHPYLTQEKLIQYCNSKGIVVTAYSPLGSPDRPWAKPEDPSILEDPRIKAIADKYNKTTAQVLIRFPIQRNLIVIPKSVTPERIAENFQVFDFELDKEDMNTLLSYNRDWRACALVSCASHRDYPFHEEF
  
Inhibitor
Name:
BDBM50022424
Synonyms:
6',8'-dichlorospiro[tetrahydro-1H-imidazole-4,4'-(3',4'-dihydro-2'H-sulphonylchromene)]-2,5-dioneH2O | CHEMBL82608
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
Clc1cc(Cl)c2c(c1)C1(CCS2(=O)=O)NC(=O)NC1=O
Structure:
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