Reaction Details Report a problem with these data
Target
Adenosylhomocysteinase
Ligand
BDBM50011180
Substrate
n/a
Meas. Tech.
ChEBML_197366
IC50
230000±n/a nM
Citation
 Borcherding, DR; Narayanan, S; Hasobe, M; McKee, JG; Keller, BT; Borchardt, RT Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 11. Molecular dissections of neplanocin A as potential inhibitors of S-adenosylhomocysteine hydrolase. J Med Chem 31:1729-38 (1988) [PubMed]  Article 
Target
Name:
Adenosylhomocysteinase
Synonyms:
AdoHcyase | CUBP | Liver copper-binding protein | S-adenosyl-L-homocysteine hydrolase | Adenosylhomocysteinase | SAHH_MOUSE | Ahcy
Type:
PROTEIN
Mol. Mass.:
47687.65
Organism:
Mouse
Description:
ChEMBL_196559
Residue:
432
Sequence:
MSDKLPYKVADIGLAAWGRKALDIAENEMPGLMRMREMYSASKPLKGARIAGCLHMTVETAVLIETLVALGAEVRWSSCNIFSTQDHAAAAIAKAGIPVFAWKGETDEEYLWCIEQTLHFKDGPLNMILDDGGDLTNLIHTKYPQLLSGIRGISEETTTGVHNLYKMMSNGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACKEGNIFVTTTGCVDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYWLKNGRRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMPINGPFKPDHYRY
  
Inhibitor
Name:
BDBM50011180
Synonyms:
CHEMBL49917 | 4-(6-Amino-purin-9-yl)-but-2-en-1-ol
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
Nc1ncnc2n(C\C=C\CO)cnc12
Structure:
Search PDB for entries with ligand similarity: