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Target
Neutral alpha-glucosidase AB
Ligand
BDBM18351
Substrate
n/a
Meas. Tech.
ChEMBL_34569 (CHEMBL649333)
IC50
1300±n/a nM
Citation
 Asano, N; Oseki, K; Kizu, H; Matsui, K Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases. J Med Chem 37:3701-6 (1994) [PubMed]  Article 
Target
Name:
Neutral alpha-glucosidase AB
Synonyms:
Alpha-glucosidase 2 | Glucosidase II subunit alpha | GANAB_HUMAN | GANAB | G2AN | KIAA0088
Type:
PROTEIN
Mol. Mass.:
106864.62
Organism:
Human
Description:
ChEMBL_218093
Residue:
944
Sequence:
MAAVAAVAARRRRSWASLVLAFLGVCLGITLAVDRSNFKTCEESSFCKRQRSIRPGLSPYRALLDSLQLGPDSLTVHLIHEVTKVLLVLELQGLQKNMTRFRIDELEPRRPRYRVPDVLVADPPIARLSVSGRDENSVELTMAEGPYKIILTARPFRLDLLEDRSLLLSVNARGLLEFEHQRAPRVSQGSKDPAEGDGAQPEETPRDGDKPEETQGKAEKDEPGAWEETFKTHSDSKPYGPMSVGLDFSLPGMEHVYGIPEHADNLRLKVTEGGEPYRLYNLDVFQYELYNPMALYGSVPVLLAHNPHRDLGIFWLNAAETWVDISSNTAGKTLFGKMMDYLQGSGETPQTDVRWMSETGIIDVFLLLGPSISDVFRQYASLTGTQALPPLFSLGYHQSRWNYRDEADVLEVDQGFDDHNLPCDVIWLDIEHADGKRYFTWDPSRFPQPRTMLERLASKRRKLVAIVDPHIKVDSGYRVHEELRNLGLYVKTRDGSDYEGWCWPGSAGYPDFTNPTMRAWWANMFSYDNYEGSAPNLFVWNDMNEPSVFNGPEVTMLKDAQHYGGWEHRDVHNIYGLYVHMATADGLRQRSGGMERPFVLARAFFAGSQRFGAVWTGDNTAEWDHLKISIPMCLSLGLVGLSFCGADVGGFFKNPEPELLVRWYQMGAYQPFFRAHAHLDTGRREPWLLPSQHNDIIRDALGQRYSLLPFWYTLLYQAHREGIPVMRPLWVQYPQDVTTFNIDDQYLLGDALLVHPVSDSGAHGVQVYLPGQGEVWYDIQSYQKHHGPQTLYLPVTLSSIPVFQRGGTIVPRWMRVRRSSECMKDDPITLFVALSPQGTAQGELFLDDGHTFNYQTRQEFLLRRFSFSGNTLVSSSADPEGHFETPIWIERVVIIGAGKPAAVVLQTKGSPESRLSFQHDPETSVLVLRKPGINVASDWSIHLR
  
Inhibitor
Name:
BDBM18351
Synonyms:
(2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol | dNM | (2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-triol, 10 | CHEMBL307429 | 1-deoxynojirimycin (DNJ) | US9181184, 1 | 1-Deoxynojirimycin | US20230339856, Compound DNJ
Type:
natural product
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: