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Target
cGMP-specific 3',5'-cyclic phosphodiesterase
Ligand
BDBM50020874
Substrate
n/a
Meas. Tech.
ChEMBL_155202 (CHEMBL762819)
IC50
5000±n/a nM
Citation
 Lee, SJ; Konishi, Y; Yu, DT; Miskowski, TA; Riviello, CM; Macina, OT; Frierson, MR; Kondo, K; Sugitani, M; Sircar, JC Discovery of potent cyclic GMP phosphodiesterase inhibitors. 2-Pyridyl- and 2-imidazolylquinazolines possessing cyclic GMP phosphodiesterase and thromboxane synthesis inhibitory activities. J Med Chem 38:3547-57 (1995) [PubMed]  Article 
Target
Name:
cGMP-specific 3',5'-cyclic phosphodiesterase
Synonyms:
CGB-PDE | Phosphodiesterase 5A (PDE5A) | Phosphodiesterase 5A | cGMP-binding cGMP-specific phosphodiesterase | Phosphodiesterase 5 (PDE5) | cGMP-specific 3',5'-cyclic phosphodiesterase | Phosphodiesterase 2 and 5 (PDE2 and PDE5) | 3',5'-cyclic phosphodiesterase | PDE5A_HUMAN | PDE5A | PDE5
Type:
Protein
Mol. Mass.:
99975.83
Organism:
Human
Description:
O76074
Residue:
875
Sequence:
MERAGPSFGQQRQQQQPQQQKQQQRDQDSVEAWLDDHWDFTFSYFVRKATREMVNAWFAERVHTIPVCKEGIRGHTESCSCPLQQSPRADNSAPGTPTRKISASEFDRPLRPIVVKDSEGTVSFLSDSEKKEQMPLTPPRFDHDEGDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEVSNNCIRLEWNKGIVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDTLTREHDANKINYMYAQYVKNTMEPLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQQEKMLINGESGQAKRN
  
Inhibitor
Name:
BDBM50020874
Synonyms:
CHEMBL332898 | (3-Chloro-phenyl)-(4-phenyl-phthalazin-1-yl)-amine
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
Clc1cccc(Nc2nnc(-c3ccccc3)c3ccccc23)c1
Structure:
Search PDB for entries with ligand similarity: