Reaction Details Report a problem with these data
Target
Steryl-sulfatase
Ligand
BDBM50355372
Substrate
n/a
Meas. Tech.
ChEMBL_203034 (CHEMBL812968)
IC50
325±n/a nM
Citation
 Ciobanu, LC; Boivin, RP; Luu-The, V; Labrie, F; Poirier, D Potent inhibition of steroid sulfatase activity by 3-O-sulfamate 17alpha-benzyl(or 4'-tert-butylbenzyl)estra-1,3,5(10)-trienes: combination of two substituents at positions C3 and c17alpha of estradiol. J Med Chem 42:2280-6 (1999) [PubMed]  Article 
Target
Name:
Steryl-sulfatase
Synonyms:
ASC | Arylsulfatase C | Steroid sulfatase | Steryl-sulfate sulfohydrolase | STS_HUMAN | STS | ARSC1
Type:
Enzyme
Mol. Mass.:
65503.66
Organism:
Human
Description:
P08842
Residue:
583
Sequence:
MPLRKMKIPFLLLFFLWEAESHAASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLGMSCHSKTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTTGFKRLVFLPLQIVGVTLLTLAALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCFMMRNYEIIQQPMSYDNLTQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFAGKSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNGCFATHVCFCFGSYVTHHDPPLLFDISKDPRERNPLTPASEPRFYEILKVMQEAADRHTQTLPEVPDQFSWNNFLWKPWLQLCCPSTGLSCQCDREKQDKRLSR
  
Inhibitor
Name:
BDBM50355372
Synonyms:
CHEMBL482212
Type:
Small organic molecule
Emp. Form.:
C25H30O2
Mol. Mass.:
n/a
SMILES:
C[C@]12CC[C@H]3[C@@H](CCc4cc(O)ccc34)[C@@H]1CC[C@@]2(O)Cc1ccccc1
Structure:
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