Reaction Details Report a problem with these data
Target
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
Ligand
BDBM50110961
Substrate
n/a
Meas. Tech.
ChEMBL_70737 (CHEMBL681127)
IC50
360±n/a nM
Citation
 Pedretti, A; Villa, L; Vistoli, G Modeling of binding modes and inhibition mechanism of some natural ligands of farnesyl transferase using molecular docking. J Med Chem 45:1460-5 (2002) [PubMed]  Article 
Target
Name:
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
Synonyms:
Protein farnesyltransferase | Protein Farnesyltransferase (PFT)/farnesyltransferase beta subunit
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of EBI is 69815
Components:
This complex has 2 components.
Component 1
Name:
Protein farnesyltransferase subunit beta
Synonyms:
CAAX farnesyltransferase subunit beta | FTase-beta | Protein farnesyltransferase subunit beta | Ras proteins prenyltransferase subunit beta | FNTB_RAT | Fntb | Protein farnesyltransferase
Type:
PROTEIN
Mol. Mass.:
48666.41
Organism:
Rat
Description:
EBI_10573
Residue:
437
Sequence:
MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD
  
Component 2
Name:
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Synonyms:
Type I protein geranyl-geranyltransferase alpha subunit | Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit | FTase-alpha | CAAX farnesyltransferase alpha subunit | GGTase-I-alpha | Ras proteins prenyltransferase alpha | FNTA_RAT | Fnta | geranylgeranyltransferase type-I | Protein farnesyltransferase
Type:
Enzyme
Mol. Mass.:
44030.14
Organism:
Rat
Description:
Recombinant rat enzyme.
Residue:
377
Sequence:
MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV
  
Inhibitor
Name:
BDBM50110961
Synonyms:
2'-hydroxy-2',6,9,12'-tetramethyl-6'-methylene-4-(4-methyl-2-oxofuryl)spiro[2,3,3a,4,5,7,9a,9b-octahydroazuleno[4,5-b]furan-3,13'-tetracyclo[10.2.2.01,10.05,9]hexadec-15'-ene]-2,7,7'-trione(arteminolide) | CHEMBL287034
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
CC(C)CC(=O)C[C@H]1CC(C)=C2C([C@H]3OC(=O)C4(CC56C=C[C@]4(C)C[C@@H]5[C@H]4OC(=O)C(=C)[C@@H]4CC[C@@]6(C)O)C13)C(C)=CC2=O |c:10,20,46,THB:15:17:25.24:20.21,26:25:17.18:20.21|
Structure:
Search PDB for entries with ligand similarity: