Reaction Details
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Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
Ligand
BDBM50110964
Substrate
n/a
Meas. Tech.
ChEMBL_70737 (CHEMBL681127)
IC50
24900±n/a nM
Citation
Pedretti, A; Villa, L; Vistoli, G Modeling of binding modes and inhibition mechanism of some natural ligands of farnesyl transferase using molecular docking. J Med Chem 45:1460-5 (2002) [PubMed] Article More Info.:
Target
Name:
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
Synonyms:
Protein farnesyltransferase | Protein Farnesyltransferase (PFT)/farnesyltransferase beta subunit
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of EBI is 69815
Components:
This complex has 2 components.
Component 1
Name:
Protein farnesyltransferase subunit beta
Synonyms:
CAAX farnesyltransferase subunit beta | FTase-beta | Protein farnesyltransferase subunit beta | Ras proteins prenyltransferase subunit beta | FNTB_RAT | Fntb | Protein farnesyltransferase
Type:
PROTEIN
Mol. Mass.:
48666.41
Organism:
Rat
Description:
EBI_10573
Residue:
437
Sequence:
MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD
Component 2
Name:
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Synonyms:
Type I protein geranyl-geranyltransferase alpha subunit | Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit | FTase-alpha | CAAX farnesyltransferase alpha subunit | GGTase-I-alpha | Ras proteins prenyltransferase alpha | FNTA_RAT | Fnta | geranylgeranyltransferase type-I | Protein farnesyltransferase
Type:
Enzyme
Mol. Mass.:
44030.14
Organism:
Rat
Description:
Recombinant rat enzyme.
Residue:
377
Sequence:
MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV
Inhibitor
Name:
BDBM50110964
Synonyms:
3-Acetoxy-10-formyl-15-hydroxy-4,4,8,12,13,16-hexamethyl-17-oxo-1,2,3,4,5,6,7,8,9,10,13,17-dodecahydro-cyclopenta[a]phenanthrene-14-carboxylic acid anion(andrastatin a)
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
CC1C(=O)[C@]2(C)C(C)=C[C@@H]3[C@](C)(CC[C@@H]4C(C)(C)[C@H](CC[C@@]34C=O)OC(C)=O)[C@]2(C([O-])=O)C1=O |c:7|
Structure:
