Reaction Details Report a problem with these data
Target
Amine oxidase [flavin-containing] B
Ligand
BDBM50292171
Substrate
n/a
Meas. Tech.
ChEMBL_123765 (CHEMBL732528)
Ki
1000000±n/a nM
Citation
 Chimenti, F; Bolasco, A; Manna, F; Secci, D; Chimenti, P; Befani, O; Turini, P; Giovannini, V; Mondovì, B; Cirilli, R; La Torre, F Synthesis and selective inhibitory activity of 1-acetyl-3,5-diphenyl-4,5-dihydro-(1H)-pyrazole derivatives against monoamine oxidase. J Med Chem 47:2071-4 (2004) [PubMed]  Article 
Target
Name:
Amine oxidase [flavin-containing] B
Synonyms:
MAO-B | Monoamine oxidase type B | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAOB) | AOFB_HUMAN | MAOB
Type:
Protein
Mol. Mass.:
58768.76
Organism:
Human
Description:
P27338
Residue:
520
Sequence:
MSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWRTMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQTRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVYYKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEERLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDRIYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTTFLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV
  
Inhibitor
Name:
BDBM50292171
Synonyms:
1-[3-(4-Hydroxy-phenyl)-5-(2-methoxy-phenyl)-4,5-dihydro-pyrazol-1-yl]-ethanone | CHEMBL293004
Type:
Small organic molecule
Emp. Form.:
C18 H18 N2 O3
Mol. Mass.:
310.34711
SMILES:
COc1ccccc1C1CC(=NN1C(C)=O)c1ccc(O)cc1 |c:11|
Structure:
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