Reaction Details Report a problem with these data
Target
S-methyl-5'-thioadenosine phosphorylase
Ligand
BDBM36494
Substrate
n/a
Meas. Tech.
ChEMBL_236 (CHEMBL615268)
Ki
0.266±n/a nM
Citation
 Evans, GB; Furneaux, RH; Schramm, VL; Singh, V; Tyler, PC Targeting the polyamine pathway with transition-state analogue inhibitors of 5'-methylthioadenosine phosphorylase. J Med Chem 47:3275-81 (2004) [PubMed]  Article 
Target
Name:
S-methyl-5'-thioadenosine phosphorylase
Synonyms:
5'-Methylthioadenosine phosphorylase (MTAP) | S-methyl-5 -thioadenosine phosphorylase | MTA phosphorylase | MTAPase | MTAP_HUMAN | MTAP | MSAP | Methylthioadenosine Phosphorylase (MTAP)
Type:
Enzyme
Mol. Mass.:
31239.23
Organism:
Human
Description:
n/a
Residue:
283
Sequence:
MASGTTTTAVKIGIIGGTGLDDPEILEGRTEKYVDTPFGKPSDALILGKIKNVDCVLLARHGRQHTIMPSKVNYQANIWALKEEGCTHVIVTTACGSLREEIQPGDIVIIDQFIDRTTMRPQSFYDGSHSCARGVCHIPMAEPFCPKTREVLIETAKKLGLRCHSKGTMVTIEGPRFSSRAESFMFRTWGADVINMTTVPEVVLAKEAGICYASIAMATDYDCWKEHEEAVSVDRVLKTLKENANKAKSLLLTTIPQIGSTEWSETLHNLKNMAQFSVLLPRH
  
Inhibitor
Name:
BDBM36494
Synonyms:
CHEMBL554965 | ImmA-Et
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: