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Target
Ileal sodium/bile acid cotransporter
Ligand
BDBM50172608
Substrate
n/a
Meas. Tech.
ChEMBL_321554 (CHEMBL881968)
IC50
2±n/a nM
Citation
 Tremont, SJ; Lee, LF; Huang, HC; Keller, BT; Banerjee, SC; Both, SR; Carpenter, AJ; Wang, CC; Garland, DJ; Huang, W; Jones, C; Koeller, KJ; Kolodziej, SA; Li, J; Manning, RE; Mahoney, MW; Miller, RE; Mischke, DA; Rath, NP; Fletcher, T; Reinhard, EJ; Tollefson, MB; Vernier, WF; Wagner, GM; Rapp, SR; Beaudry, J; Glenn, K; Regina, K; Schuh, JR; Smith, ME; Trivedi, JS; Reitz, DB Discovery of potent, nonsystemic apical sodium-codependent bile acid transporter inhibitors (Part 1). J Med Chem 48:5837-52 (2005) [PubMed]  Article 
Target
Name:
Ileal sodium/bile acid cotransporter
Synonyms:
Apical sodium-dependent bile acid transporter | Ileal Na(+)/bile acid cotransporter | Ileal sodium-dependent bile acid transporter | IBAT | Ileal bile acid transporter | NTCP2_HUMAN | ASBT | SLC10A2 | ISBT | NTCP2 | Ileal bile acid transporter/bile acid cotransporter
Type:
Enzyme
Mol. Mass.:
37714.89
Organism:
Human
Description:
SLC10A2
Residue:
348
Sequence:
MNDPNSCVDNATVCSGASCVVPESNFNNILSVVLSTVLTILLALVMFSMGCNVEIKKFLGHIKRPWGICVGFLCQFGIMPLTGFILSVAFDILPLQAVVVLIIGCCPGGTASNILAYWVDGDMDLSVSMTTCSTLLALGMMPLCLLIYTKMWVDSGSIVIPYDNIGTSLVSLVVPVSIGMFVNHKWPQKAKIILKIGSIAGAILIVLIAVVGGILYQSAWIIAPKLWIIGTIFPVAGYSLGFLLARIAGLPWYRCRTVAFETGMQNTQLCSTIVQLSFTPEELNVVFTFPLIYSIFQLAFAAIFLGFYVAYKKCHGKNKAEIPESKENGTEPESSFYKANGGFQPDEK
  
Inhibitor
Name:
BDBM50172608
Synonyms:
(4R,5R)-3,3-Dibutyl-7-dimethylamino-9-methoxy-5-(4-methoxy-phenyl)-1,1-dioxo-2,3,4,5-tetrahydro-1H-1lambda*6*-benzo[b]thiepin-4-ol | CHEMBL372275
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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