Reaction Details Report a problem with these data
Target
3-hydroxyacyl-[acyl-carrier-protein] dehydratase
Ligand
BDBM7460
Substrate
n/a
Meas. Tech.
ChEMBL_361103 (CHEMBL859169)
IC50
1500±n/a nM
Citation
 Tasdemir, D; Lack, G; Brun, R; Rüedi, P; Scapozza, L; Perozzo, R Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. J Med Chem 49:3345-53 (2006) [PubMed]  Article 
Target
Name:
3-hydroxyacyl-[acyl-carrier-protein] dehydratase
Synonyms:
Fatty acid synthase
Type:
PROTEIN
Mol. Mass.:
26222.50
Organism:
malaria parasite P. falciparum
Description:
ChEMBL_983601
Residue:
230
Sequence:
MRFLIIHIAVIVLPFVLMIDVKRENSFFLRHSPKRLYKKADYNNMYDKIIKKQQNRIYDVSSQINQDNINGQNISFNLTFPNYDTSIDIEDIKKILPHRYPFLLVDKVIYMQPNKTIIGLKQVSTNEPFFNGHFPQKQIMPGVLQIEALAQLAGILCLKSDDSQKNNLFLFAGVDGVRWKKPVLPGDTLTMQANLISFKSSLGIAKLSGVGYVNGKVVINISEMTFALSK
  
Inhibitor
Name:
BDBM7460
Synonyms:
2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-chromone;hydrate | 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one | CHEMBL50 | 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-chromen-4-one | Quercetin | Quercetin (21) | Quercetin (Qur) | US9180183, Quercetin | Quercetin (10) | med.21724, Compound 4 | US11021454, Compound Quercetin
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: