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Target
Cyclin-dependent kinase 5 activator 1
Ligand
BDBM50132003
Substrate
n/a
Meas. Tech.
ChEMBL_365406 (CHEMBL867889)
IC50
100±n/a nM
Citation
 Ferandin, Y; Bettayeb, K; Kritsanida, M; Lozach, O; Polychronopoulos, P; Magiatis, P; Skaltsounis, AL; Meijer, L 3'-Substituted 7-halogenoindirubins, a new class of cell death inducing agents. J Med Chem 49:4638-49 (2006) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 5 activator 1
Synonyms:
CDK5/p35 | Cyclin-Dependent Kinase 5 (CDK5) | Cyclin-dependent kinase 5 regulatory subunit 1 | Cyclin-dependent kinase 5/CDK5 activator 1
Type:
Protein Complex
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Cyclin-dependent kinase 5
Synonyms:
Cyclin-dependent-like kinase 5 (CDK5) | Cell division protein kinase 5 | Serine/threonine-protein kinase PSSALRE | Tau protein kinase II catalytic subunit | Cyclin-dependent-like kinase 5 | CDK5_HUMAN | CDK5 | CDKN5 | PSSALRE
Type:
Enzyme Subunit
Mol. Mass.:
33308.61
Organism:
Human
Description:
Residue:
292
Sequence:
MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP
  
Component 2
Name:
Cyclin-dependent kinase 5 activator 1
Synonyms:
TPKII regulatory subunit | Cyclin-dependent kinase 5 regulatory subunit 1 | CD5R1_HUMAN | CDK5R1 | CDK5R | NCK5A
Type:
Enzyme Subunit
Mol. Mass.:
34077.43
Organism:
Human
Description:
Q15078
Residue:
307
Sequence:
MGTVLSLSPSYRKATLFEDGAATVGHYTAVQNSKNAKDKNLKRHSIISVLPWKRIVAVSAKKKNSKKVQPNSSYQNNITHLNNENLKKSLSCANLSTFAQPPPAQPPAPPASQLSGSQTGGSSSVKKAPHPAVTSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYMGNEISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKRLLLGLDR
  
Inhibitor
Name:
BDBM50132003
Synonyms:
(Z)-1H,1''H-[2,3'']Biindolylidene-3,2''-dione 3-oxime | 1H,1''H-[2,3'']Biindolylidene-3,2''-dione 3-oxime | 3-(3-(hydroxyimino)indolin-2-ylidene)indolin-2-one | 1H,1'H-[2,3']Biindolylidene-3,2'-dione 3-oxime | (Z)-1H,1'H-[2,3']Biindolylidene-3,2'-dione 3-oxime | CHEMBL126077
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
Oc1[nH]c2ccccc2c1-c1[nH]c2ccccc2c1N=O |(1.71,2.82,;2.18,1.35,;3.65,.86,;3.62,-.68,;4.77,-1.7,;4.44,-3.2,;2.97,-3.66,;1.85,-2.62,;2.18,-1.13,;1.27,.12,;-.27,.12,;-1.18,-1.12,;-2.65,-.64,;-3.96,-1.41,;-5.29,-.64,;-5.29,.9,;-3.96,1.68,;-2.63,.9,;-1.16,1.38,;-.69,2.84,;-1.7,3.98,)|
Structure:
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