Reaction Details Report a problem with these data
Target
Growth hormone secretagogue receptor type 1
Ligand
BDBM50235838
Substrate
n/a
Meas. Tech.
ChEMBL_462860 (CHEMBL928778)
EC50
0.34±n/a nM
Citation
 Li, J; Chen, SY; Tao, S; Wang, H; Li, JJ; Swartz, S; Musial, C; Hernandez, AA; Flynn, N; Murphy, BJ; Beehler, B; Dickinson, KE; Giupponi, L; Grover, G; Seethala, R; Sleph, P; Slusarchyk, D; Yan, M; Humphreys, WG; Zhang, H; Ewing, WR; Robl, JA; Gordon, D; Tino, JA Design and synthesis of tetrazole-based growth hormone secretagogue: the SAR studies of the O-benzyl serine side chain. Bioorg Med Chem Lett 18:1825-9 (2008) [PubMed]  Article 
Target
Name:
Growth hormone secretagogue receptor type 1
Synonyms:
Ghrelin receptor 1a (GHS-R1a) | GH-releasing peptide receptor | Ghrelin Receptor (Growth Hormone Secretagogue Receptor Type 1) | GHS-R | GHRP | GHSR_HUMAN | GHSR | Ghrelin receptor
Type:
Receptor
Mol. Mass.:
41334.57
Organism:
Human
Description:
Receptor binding studies use plasma membranes from LLC PK-1 cells transiently transfected with hGHSR1a.
Residue:
366
Sequence:
MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
  
Inhibitor
Name:
BDBM50235838
Synonyms:
(4-hydroxy-butyl)-carbamic acid 2-{5-[(S)-1-(2-amino-2-methyl-propionylamino)-2-(biphenyl-2-ylmethoxy)-ethyl]-tetrazol-1-yl}-ethyl ester | CHEMBL539929
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
CC(C)(N)C(=O)N[C@H](COCc1ccccc1-c1ccccc1)c1nnnn1CCOC(=O)NCCCCO
Structure:
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