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Target
Caspase-2
Ligand
BDBM79403
Substrate
n/a
Meas. Tech.
ChEMBL_476696 (CHEMBL933486)
EC50
8500±n/a nM
Citation
 Goode, DR; Totten, RK; Heeres, JT; Hergenrother, PJ Identification of promiscuous small molecule activators in high-throughput enzyme activation screens. J Med Chem 51:2346-9 (2008) [PubMed]  Article 
Target
Name:
Caspase-2
Synonyms:
Caspase-2 subunit p18 | Neural precursor cell expressed developmentally down-regulated protein 2 | ICH-1L/1S | ICH-1 protease | Caspase-2 subunit p12 | Caspase-2 subunit p13 | NEDD-2 | CASP-2 | CASP2_HUMAN | CASP2 | ICH1 | NEDD2
Type:
Enzyme
Mol. Mass.:
50688.29
Organism:
Human
Description:
P42575
Residue:
452
Sequence:
MAAPSAGSWSTFQHKELMAADRGRRILGVCGMHPHHQETLKKNRVVLAKQLLLSELLEHLLEKDIITLEMRELIQAKVGSFSQNVELLNLLPKRGPQAFDAFCEALRETKQGHLEDMLLTTLSGLQHVLPPLSCDYDLSLPFPVCESCPLYKKLRLSTDTVEHSLDNKDGPVCLQVKPCTPEFYQTHFQLAYRLQSRPRGLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEMQEKLQNFAQLPAHRVTDSCIVALLSHGVEGAIYGVDGKLLQLQEVFQLFDNANCPSLQNKPKMFFIQACRGDETDRGVDQQDGKNHAGSPGCEESDAGKEKLPKMRLPTRSDMICGYACLKGTAAMRNTKRGSWYIEALAQVFSERACDMHVADMLVKVNALIKDREGYAPGTEFHRCKEMSEYCSTLCRHLYLFPGHPPT
  
Inhibitor
Name:
BDBM79403
Synonyms:
N,N''-bis(3-azanylpropyl)butane-1,4-diamine;hydrochloride | N,N''-bis(3-aminopropyl)butane-1,4-diamine;hydrochloride | Spermine | MLS002472980 | cid_5351186 | CHEMBL23194 | SMR001397086 | spermidine 3HCl | N,N'-bis(3-aminopropyl)butane-1,4-diamine | 3-aminopropyl-[4-(3-aminopropylamino)butyl]amine;hydrochloride
Type:
Small organic molecule
Emp. Form.:
C10H26N4
Mol. Mass.:
202.22
SMILES:
C(CCNCCCN)CNCCCN
Structure:
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